PXD019008 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Discovery of biomarker candidates associated with the risk of short- and long-term relapse after infliximab withdrawal in Crohns patients: a proteomics-based study |
Description | Objective: A subset of Crohns disease (CD) patients experiences long-term remission after infliximab withdrawal. Biomarkers are needed to identify those patients.Design: New biomarkers of relapse were searched in the baseline serum of CD patients stopping infliximab when they were under combined therapy (antimetabolite and infliximab) and stable clinical remission (STORI cohort, n=102). From shotgun proteomics experiment (discovery step), biomarker candidates were identified and further targeted by selected reaction monitoring (verification step). The dataset was stratified to search for markers of short- (<6 months) or long-term relapse (>6 months). The risk of relapse and the predicting capacity associated with biomarker candidates were evaluated using univariate Cox model and log-rank statistic, respectively. To test their complementary predicting capacity, biomarker candidates were systematically combined in pairs. Results: Distinct biomarker candidates were associated with the risk (hazard ratio: HR) of short- (15 proteins, 2.9
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HostingRepository | PRIDE |
AnnounceDate | 2020-10-19 |
AnnouncementXML | Submission_2020-10-18_22:49:32.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | nicolas Pierre |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Synapt MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-05-06 01:10:49 | ID requested | |
⏵ 1 | 2020-10-18 22:49:33 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Human, serum, Crohn’s disease, relapse prediction |
Contact List
Edouard LOUIS |
contact affiliation | University Hopital of Liege(CHU of Liege) and Translational gastroenterology laboratory, GIGA institute, University of Liege (Uliege) |
contact email | edouard.louis@uliege.be |
lab head | |
nicolas Pierre |
contact affiliation | GIGA-R - Translational Gastroenterology, Liège University |
contact email | nicolas.pierre@uliege.be |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD019008
- Label: PRIDE project
- Name: Discovery of biomarker candidates associated with the risk of short- and long-term relapse after infliximab withdrawal in Crohns patients: a proteomics-based study