PXD018995-2

PXD018995 is an original dataset announced via ProteomeXchange.

Title	SIRT3 interactions and mitochondrial proteome during HCMV infection
Description	SIRT3 has been shown to inhibit HCMV infection, but the mechanism under the antiviral effect is not clear. To identify the mediator of SIRT3 antiviral function, we aim to identify and quantify SIRT3 interactions during HCMV infection. A set of large-scale IPs were performed to determine the specific interactions with SIRT3 during infection, while small-scale IPs were conducted to determine the temporal interactions over the life cycle of infection. The mitochondrial proteome was used to characterize the changes of protein abundances after infection, and it was used for the normalization of acetylation.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:20:41.052.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xinlei Sheng
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	carbamoylated residue; phosphorylated residue; monohydroxylated residue; acetylated residue; deamidated residue
Instrument	Q Exactive HF; LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-05 01:20:27	ID requested
1	2021-04-01 13:47:58	announced
⏵ 2	2024-10-22 05:20:41	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: HCMV, mitochondrial proteome, IP-MS,SIRT3

Ileana M. Cristea
contact affiliation	Department of molecular biology, Princeton University, US
contact email	icristea@princeton.edu
lab head
Xinlei Sheng
contact affiliation	Princeton University
contact email	xsheng@princeton.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD018995

PRIDE project URI

• PRIDE
  1. PXD018995
     1. Label: PRIDE project
     2. Name: SIRT3 interactions and mitochondrial proteome during HCMV infection