PXD018958-1
PXD018958 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nanobiointerface |
| Description | Nanomaterials in blood must mitigate the immune response to have prolonged residency, a property that is highly relevant to biocompatibility, toxicity, and the generation of long acting therapeutics. The composition of the protein corona that forms at the nano-biointerface may be directing this, however, it is currently unknown the possible correlation of corona composition with blood residency. We developed a panel of new soft single molecule polymer nanomaterials (SMPNs) with varying circulation times in mice (t1/2 ~22 to 65 h) and used proteomics to probe the nano-biointerface to elucidate the mechanism of blood residency of nanomaterials. The composition of the protein opsonins on SMPNs was qualitatively and quantitatively dynamic with time in circulation, and SMPNs that circulated longer were able to clear some of the initial surface-bound common opsonins, including immunoglobulins, complement, and coagulation proteins. This continuous remodelling of protein opsonins, a phenomenon first of its kind observed, may be a decisive step in directing elimination or residence of the reported soft nanomaterials in vivo. |
| HostingRepository | MassIVE |
| AnnounceDate | 2020-05-13 |
| AnnouncementXML | Submission_2020-05-13_15:00:57.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jason Rogalski |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Oxidation; Acetyl |
| Instrument | instrument model |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-05-03 12:27:32 | ID requested | |
| ⏵ 1 | 2020-05-13 15:00:57 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Circulating nanoparticle |
Contact List
| Jayachandran N. Kizhakkedathu | |
|---|---|
| contact affiliation | University of British Columbia |
| contact email | jay@pathology.ubc.ca |
| lab head | |
| Jason Rogalski | |
| contact affiliation | UBC |
| contact email | rogy@mail.ubc.ca |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000085364/ |
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