PXD018873-1

PXD018873 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	eEF2K activity determines synergy to PI3K and MEK inhibitors in combination in cancer cells
Description	To understand the mechanisms involved in synergy to PI3Ki + MEKi treatment, we performed a global phosphoproteomics analysis in 3 different cancer cell lines treated with a MEK inhibitor (Trametinib) and a PI3K inhibitor (Pictilisib) at 500 nM individually or in combination for one hour.
HostingRepository	PRIDE
AnnounceDate	2022-04-26
AnnouncementXML	Submission_2022-04-25_19:23:03.730.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD018873
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Maruan Hijazi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Phospho; Oxidation; Carbamidomethyl; Gln->pyro-Glu
Instrument	Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-28 16:44:53	ID requested
⏵ 1	2022-04-25 19:23:04	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: phosphoproteomics, kinase signalling, eEF2K, cancer, biomarkers

submitter keyword: phosphoproteomics, kinase signalling, eEF2K, cancer, biomarkers

Contact List

Pedro Cutillas
contact affiliation	Barts Cancer Institute. Queen Mary University of London
contact email	p.cutillas@qmul.ac.uk
lab head
Maruan Hijazi
contact affiliation	BARTS CANCER INSTITUTE. QUEEN MARY UNIVERSITY OF LONDON
contact email	m.hijazivega@qmul.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD018873
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD018873

PRIDE project URI

Repository Record List

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