PXD018848-1

PXD018848 is an original dataset announced via ProteomeXchange.

Title	Systematic Analysis of the Lysine Crotonylome and multiple PTM analysis (acetylation, succinylation and crotonylation) in Candida albicans
Description	LC-MS/MS was used to carry out the analysis of the crotonylome in C. albicans (Candida albicans) comprehensively in our study. Generally, 5242 specific crotonylated sites of 1584 crotonylated proteins were detected among 9038 proteins in C. albicans. The crotonylome involved in the regulation of metabolism through the bioinformatics analysis. Moreover, the crotonylated proteins related to biosynthesis and carbon metabolism were prevalence phenomenon. Moreover, a universal rule were found in crotonylated motifs: D/E were found in the position (+1, +2 or +3) and K/R were found in the position (+5 or +6) of the residue; A/E/F/G/P/W/Y were found in the -1 position and A/K/R were found in the position (-5, -6, -7 or -8) of the residue. As far as we know, crotonylated histone sites that screened in C. albicans of this study have not been reported before. Furthermore, a variety of connections in PPI (protein-protein interaction network) of ribosome, oxidative phosphorylation, nucleus and proteasome were modified by acetylation, succinylation and crotonylation. Sir2 inhibitor AK-1 was able to promote histone lysine crotonylation and non-histone lysine crotonylation.
HostingRepository	PRIDE
AnnounceDate	2021-01-08
AnnouncementXML	Submission_2021-01-08_00:00:49.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	xiaowei zhou
SpeciesList	scientific name: Candida albicans; NCBI TaxID: 5476;
ModificationList	N6-crotonyl-L-lysine
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-28 01:09:40	ID requested
⏵ 1	2021-01-08 00:00:49	announced

Dataset with its publication pending

submitter keyword: C. albicans

Crotonylome

Histone

Lysine crotonylation motif

PPI

Xiaofang Li
contact affiliation	Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China
contact email	zhouxw@pumcderm.cams.cn
lab head
xiaowei zhou
contact affiliation	Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs
contact email	zhouxw@pumcderm.cams.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD018848
     1. Label: PRIDE project
     2. Name: Systematic Analysis of the Lysine Crotonylome and multiple PTM analysis (acetylation, succinylation and crotonylation) in Candida albicans