PXD018781 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii parasites |
Description | Apicomplexan parasites cause numerous diseases in humans and animals, including malaria (Plasmodium species) and toxoplasmosis (Toxoplasma gondii). Despite being a major drug target, the protein composition of the coenzyme Q:cytochrome c oxidoreductase complex (Complex III) in these parasites was previously unknown. Our work highlights the divergence of mitochondrial ETC Complex III composition in apicomplexan parasites and provides a broader understanding of Complex III evolution. Our study also provides important insights into what sets this major drug target apart from the equivalent complex in host species. Future studies can build on our findings to reveal how novel subunits contribute to Complex III function to further investigate this important drug target. |
HostingRepository | PRIDE |
AnnounceDate | 2021-01-27 |
AnnouncementXML | Submission_2021-01-26_23:03:01.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD018781 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Pierre Faou |
SpeciesList | scientific name: Toxoplasma gondii GAB3-2007-GAL-DOM9; NCBI TaxID: 1204162; |
ModificationList | Carbamidomethyl; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-04-24 01:28:05 | ID requested | |
⏵ 1 | 2021-01-26 23:03:01 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Toxoplasma gondii, Apicomplexa, mitochondria, electron transport chain, coenzyme Q:cytochrome c oxidoreductase |
Contact List
Giel G. van Dooren |
contact affiliation | Research School of Biology, Australian National University, Canberra, Australia |
contact email | giel.vandooren@anu.edu.au |
lab head | |
Pierre Faou |
contact affiliation | La Trobe University |
contact email | P.faou@latrobe.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD018781
- Label: PRIDE project
- Name: Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii parasites