PXD018687-1
PXD018687 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Physiological tau interactome in brain and its link to tauopathies_complete submission |
Description | Alzheimer's disease (AD) and most of other tauopathies are incurable neurodegenerative diseases with unpleasant symptoms and consequences. The common hallmark of all these diseases is tau pathology but its connection with disease progress has not been completely understood so far. Therefore, uncovering novel tau interacting partners and pathology affected molecular pathways can reveal the causes of diseases as well as potential targets for development of AD treatment. Despite of large amount of known tau interacting partners, limited number of studies focused on in vivo tau interactions in disease or healthy conditions are available. Here, we applied an in vivo crosslinking approach, capable of capturing weak and transient protein-protein interactions, to a unique transgenic rat model of progressive tau pathology similar to human AD. We have identified 175 potential novel and known tau interacting proteins by MALDI-TOF mass spectrometry. Several of the most promising candidates for potential drug development were selected for validation by coimmunoprecipitation and colocalization experiments in animal and cellular models. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-07 |
AnnouncementXML | Submission_2024-10-07_10:39:47.138.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD018687 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Jozef Hanes |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | Deamidated; Formyl; Oxidation; Carbamidomethyl; formylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | ultraflex |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-04-20 08:45:32 | ID requested | |
⏵ 1 | 2024-10-07 10:39:47 | announced |
Publication List
Sinsky J, Majerova P, Kovac A, Kotlyar M, Jurisica I, Hanes J, Physiological Tau Interactome in Brain and Its Link to Tauopathies. J Proteome Res, 19(6):2429-2442(2020) [pubmed] |
10.1021/acs.jproteome.0c00137; |
10.6019/PXD018687; |
Keyword List
submitter keyword: mass spectrometry, Alzheimer's disease, in vivo crosslinking, tau interaction partners,tau protein, tauopathies, tau pathology |
Contact List
Dr. Andrej Kovac | |
---|---|
contact affiliation | Laboratory of Proteomics and Metabolomics, Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska cesta 9, 84510, Bratislava, Slovakia |
contact email | andrej.kovac@savba.sk |
lab head | |
Jozef Hanes | |
contact affiliation | Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska cesta 9, 84510, Bratislava, Slovakia |
contact email | jozef.hanes@savba.sk |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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