PXD018629-1
PXD018629 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Phosphorylated Tau Interactome in the Human Alzheimers Disease Brain |
Description | Accumulation of phosphorylated tau is a key pathological feature of Alzheimers disease. Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and formation of neurofibrillary tangles. The pathological actions of phosphorylated tau are mediated by surrounding neuronal proteins, however a comprehensive understanding of the proteins that phosphorylated tau interacts with in Alzheimers disease is surprisingly limited. Therefore, the aim of this study was to determine the phosphorylated tau interactome for the first time. To do this we used two complementary proteomics approaches: First, quantitative proteomics was performed on neurofibrillary tangles microdissected from patients with advanced Alzheimers disease. Second, affinity purification-mass spectrometry was used to identify which of these proteins specifically bound to phosphorylated tau. |
HostingRepository | MassIVE |
AnnounceDate | 2020-09-04 |
AnnouncementXML | Submission_2020-09-04_08:19:27.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Beatrix Ueberheide |
SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | Phospho |
Instrument | Q Exactive; Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-04-17 13:11:35 | ID requested | |
⏵ 1 | 2020-09-04 08:19:28 | announced |
Publication List
Drummond E, Pires G, MacMurray C, Askenazi M, Nayak S, Bourdon M, Safar J, Ueberheide B, Wisniewski T, Phosphorylated tau interactome in the human Alzheimer's disease brain. Brain, 143(9):2803-2817(2020) [pubmed] |
Keyword List
submitter keyword: Tau , neurofibrillary tangles, affinity purifications, laser capture microdissection, label-free, AD |
Contact List
Beatrix Ueberheide | |
---|---|
contact affiliation | NYU School of Medicine |
contact email | beatrix.ueberheide@nyulangone.org |
lab head | |
Beatrix Ueberheide | |
contact affiliation | NYU School of Medicine |
contact email | beatrixueberheide@gmail.com |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000085305/ |