PXD018416-1

PXD018416 is an original dataset announced via ProteomeXchange.

Title	Global Proteomic Profiling in Chronic Iron-Exposed Fallopian Tube Secretory Epithelial Cells
Description	We previously published (Oncogenesis, Rockfield et al., 2019) that chronic iron exposure (with ferric ammonium citrate, FAC) in immortalized fallopian tube secretory epithelial cells resulted in increased growth and migratory propensity. Our focused analyses identified a subset of oncogenic markers, including EVI1 (amplified at 3q26.2 in high grade serous epithelial ovarian tumors), that were altered following long term iron treatment. Herein, we have extended these studies to global proteomics analyses via a mass spectrometry (MS)-based approach.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-08_23:47:13.883.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stanley Stevens
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-07 07:52:33	ID requested
⏵ 1	2021-09-08 23:47:14	announced

Chhabra R, Rockfield S, Guergues J, Nadeau OW, Hill R, Stevens SM, Nanjundan M, Global miRNA/proteomic analyses identify miRNAs at 14q32 and 3p21, which contribute to features of chronic iron-exposed fallopian tube epithelial cells. Sci Rep, 11(1):6270(2021) [pubmed]

submitter keyword: proteomic profiling, ferric ammonium citrate, fallopian tube secretory epithelial cells, ovarian cancer, initiation events

Meera Nanjundan
contact affiliation	Department of Cell Biology, Microbiology, and Molecular Biology University of South Florida Tampa, FL, USA 33620
contact email	mnanjund@usf.edu
lab head
Stanley Stevens
contact affiliation	Albany College of Pharmacy and Health Sciences
contact email	stanley.stevens@acphs.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD018416

PRIDE project URI

• PRIDE
  1. PXD018416
     1. Label: PRIDE project
     2. Name: Global Proteomic Profiling in Chronic Iron-Exposed Fallopian Tube Secretory Epithelial Cells