PXD018344 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Identification of auto mono-ADP-ribosylation sites on SIRT6 and SIRT7 |
Description | The aim of this project was to identify the auto mono-ADP-ribosylation sites on SIRT6 and SIRT7 to study the effect of the point mutations S56A and N189A respectively on their ADP-ribosylation activity. In addition, the mono-ADP-ribosylation pattern of SIRT7 was obtained in cells under different stress conditions (UV, H2O2, ionizing Irradiation and glucose starvation). |
HostingRepository | PRIDE |
AnnounceDate | 2021-04-20 |
AnnouncementXML | Submission_2021-04-19_21:34:31.450.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Joan Josep Bech-Serra |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | adenosine diphosphoribosyl (ADP-ribosyl) modified residue; phosphorylated residue; acetylated residue |
Instrument | Orbitrap Eclipse; Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-04-03 00:15:38 | ID requested | |
1 | 2021-04-19 08:04:35 | announced | |
⏵ 2 | 2021-04-19 21:34:32 | announced | 2021-04-20: Updated project metadata. |
Publication List
10.1126/SCIADV.AAZ2590; |
Simonet NG, Thackray JK, Vazquez BN, Ianni A, Espinosa-Alcantud M, Morales-Sanfrutos J, Hurtado-Bag, è, s S, Sabid, ó E, Buschbeck M, Tischfield J, De La Torre C, Esteller M, Braun T, Olivella M, Serrano L, Vaquero A, SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1. Sci Adv, 6(30):eaaz2590(2020) [pubmed] |
Keyword List
submitter keyword: sirtuins |
SirT7 |
ADP-ribosylation |
macroH2A |
glucose starvation |
chromatin |
calorie restriction |
aging |
Orbitrap Lumos |
Orbitrap Eclipse |
Contact List
Alex Vaquero |
contact affiliation | Chromatin Biology Laboratory Josep Carreras Leukaemia Research Institute (IJC) Ctra de Can Ruti, Camí de les Escoles s/n 08916, Badalona, Barcelona, Spain |
contact email | avaquero@carrerasresearch.org |
lab head | |
Joan Josep Bech-Serra |
contact affiliation | Proteomics Unit - Josep Carreras Leukaemia Research Institute |
contact email | jbech@carrerasresearch.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD018344 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD018344
- Label: PRIDE project
- Name: Identification of auto mono-ADP-ribosylation sites on SIRT6 and SIRT7