PXD018302-1

PXD018302 is an original dataset announced via ProteomeXchange.

Title	VESTIGIAL-LIKE 1 IS A SHARED TARGETABLE CANCER-PLACENTA ANTIGEN EXPRESSED BY PANCREATIC AND BASAL-LIKE BREAST CANCERS
Description	Cytotoxic T lymphocyte (CTL)-based cancer immunotherapies have shown great promise for inducing clinical regression by targeting tumor-associated antigens (TAA). To expand the TAA landscape of pancreatic ductal adenocarcinoma (PDAC), we performed tandem mass spectrometry analysis of HLA class I-bound peptides from tumor specimens of 35 PDAC patients. This led to the identification of a shared HLA-A*0101 restricted peptide derived from co-transcriptional activator Vestigial-like 1 (VGLL1), a novel putative TAA demonstrating overexpression in multiple tumor types and low or absent transcript expression in essential normal tissues. VGLL1-specific CTLs isolated and expanded from the blood of a male PDAC patient showed the capacity to recognize and kill in an antigen-specific manner a majority of HLA-A*0101 allogeneic tumor cell lines derived not only from PDAC, but also bladder, ovarian, gastric, lung and basal-like breast cancers. Gene expression profiling revealed that VGLL1 is a member of a unique group of cancer-placenta antigens (CPA) that may constitute immunotherapeutic TAA targets for patients with multiple different cancer types.
HostingRepository	PRIDE
AnnounceDate	2020-10-19
AnnouncementXML	Submission_2020-10-18_22:22:41.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gregory Lizee
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-31 02:22:39	ID requested
⏵ 1	2020-10-18 22:22:41	announced
2	2020-11-09 07:09:09	announced	2020-11-09: Updated publication reference for PubMed record(s): 33087697.
3	2024-10-22 05:13:32	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: HUMAN,MHC,PDAC

Greg Lizee
contact affiliation	The University of Texas, MD Anderson Cancer Center, Department of Melanoma Med Oncology, Houston, TX 77045
contact email	glizee@mdanderson.org
lab head
Gregory Lizee
contact affiliation	University of Texas M.D. Anderson Cancar Center
contact email	glizee@mdanderson.org
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD018302
     1. Label: PRIDE project
     2. Name: VESTIGIAL-LIKE 1 IS A SHARED TARGETABLE CANCER-PLACENTA ANTIGEN EXPRESSED BY PANCREATIC AND BASAL-LIKE BREAST CANCERS