PXD018260 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Quantitative phosphoproteomic analysis of ARPE-19 cells in response to LPS |
Description | Overwhelming and persistent inflammation of retinal pigment epithelium (RPE) induces destructive changes in retinal environment by invoking immune activation. In this study, we aimed to investigate RPE-specific biological and metabolic response against intense inflammation, and identify molecular characteristics determining pathological progression. Here, we performed quantitative analyses of phosphoproteome of lipopolysaccharide (LPS)-stimulated human derived RPE cell line ARPE-19 using the latest isobaric TMT labeling approach coupled with high-resolution mass spectrometry. |
HostingRepository | PRIDE |
AnnounceDate | 2021-09-09 |
AnnouncementXML | Submission_2021-09-08_18:50:49.908.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Dohyun Han |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-03-30 01:11:05 | ID requested | |
⏵ 1 | 2021-09-08 18:50:50 | announced | |
Publication List
Song J, Han D, Lee H, Kim DJ, Cho JY, Park JH, Seok SH, A Comprehensive Proteomic and Phosphoproteomic Analysis of Retinal Pigment Epithelium Reveals Multiple Pathway Alterations in Response to the Inflammatory Stimuli. Int J Mol Sci, 21(9):(2020) [pubmed] |
Keyword List
submitter keyword: ARPE-19, LPS, human |
Contact List
Dohyun Han |
contact affiliation | Proteomics core facility, Biomedical Research Institute, Seoul National University Hospital |
contact email | hdh03@snu.ac.kr |
lab head | |
Dohyun Han |
contact affiliation | Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital |
contact email | hdh03@snu.ac.kr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD018260
- Label: PRIDE project
- Name: Quantitative phosphoproteomic analysis of ARPE-19 cells in response to LPS