PXD018143-3

PXD018143 is an original dataset announced via ProteomeXchange.

Title	Human nucleolar RNA pol I interacting proteins identified by immuno-precipitation and mass spectrometry
Description	Ribosome biogenesis is a highly regulated multistep process that controls cell growth and proliferation. The first and key regulatory step of ribosome biogenesis is represented by the transcription of ribosomal RNA (rRNA) genes by RNA polymerase (pol) I in the nucleolus. Activity of RNA pol I is tightly regulated by interactions with many auxiliary factors that mediate promoter recognition and contribute to transcription initiation, elongation and termination. In this study we were able to identify by mass spectrometry some of the known components of the RNA pol I transcribing machinery, and at the same time we identify some novel interactors.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:03:12.988.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Francesca Fabretti
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-23 01:17:12	ID requested
1	2020-05-06 05:58:39	announced
2	2020-05-24 23:08:50	announced	2020-05-25: Updated publication reference for PubMed record(s): 32421830.
⏵ 3	2024-10-22 05:03:13	announced	2024-10-22: Updated project metadata.

10.1093/nar/gkaa344;

Sorino C, Catena V, Bruno T, De Nicola F, Scalera S, Bossi G, Fabretti F, Mano M, De Smaele E, Fanciulli M, Iezzi S, Che-1/AATF binds to RNA polymerase I machinery and sustains ribosomal RNA gene transcription. Nucleic Acids Res, 48(11):5891-5906(2020) [pubmed]

submitter keyword: human RNApolI interactors from nucleoli

Bernhard Schermer
contact affiliation	University of Cologne - Internal Medicine II
contact email	bernhard.schermer@uk-koeln.de
lab head
Francesca Fabretti
contact affiliation	Uniklinik Köln
contact email	francesca.fabretti@uk-koeln.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD018143

PRIDE project URI

• PRIDE
  1. PXD018143
     1. Label: PRIDE project
     2. Name: Human nucleolar RNA pol I interacting proteins identified by immuno-precipitation and mass spectrometry