PXD018100-1

PXD018100 is an original dataset announced via ProteomeXchange.

Title	Toxicity of Ppz1 protein phosphatase involves multiple targets
Description	over-expression of Ppz1 is deleterious for yeast cells. Recent studies in our laboratory demonstrated that the over-expression of a catalytically impaired version of Ppz1 (Ppz1R451L) is not toxic, suggesting that the excess of Ppz1 phosphatase activity was responsible for toxicity, possibly due to changes in yeast phosphoproteome [1]. Because the molecular basis of this toxicity are still unknown, a global yeast phosphoproteomic assay was designed to gain insight into this phenomenon.
HostingRepository	PRIDE
AnnounceDate	2020-10-05
AnnouncementXML	Submission_2020-10-04_23:32:06.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Diego Velázquez
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-18 18:08:28	ID requested
⏵ 1	2020-10-04 23:32:07	announced
2	2020-10-05 22:39:30	announced	2020-10-06: Updated project metadata.
3	2020-10-06 22:54:03	announced	2020-10-07: Updated project metadata.
4	2020-10-06 22:54:13	announced	2020-10-07: Updated project metadata.
5	2024-10-22 05:13:20	announced	2024-10-22: Updated project metadata.

Vel, á, zquez D, Albacar M, Zhang C, Calaf, í C, L, ó, pez-Malo M, Torres-Torronteras J, Mart, í R, Kovalchuk SI, Pinson B, Jensen ON, Daignan-Fornier B, Casamayor A, Ari, ñ, o J, Yeast Ppz1 protein phosphatase toxicity involves the alteration of multiple cellular targets. Sci Rep, 10(1):15613(2020) [pubmed]

submitter keyword: Yeast, antifungal target, phosphatase, S. cerevisiae,

Joaquin Ariño Carmona
contact affiliation	Head of the Biochemestry an molecular biology department
contact email	Joarin.Arino@uab.cat
lab head
Diego Velázquez
contact affiliation	Universitat Autonoma de Bercelona
contact email	Diego.Velazquez@uab.cat
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/10/PXD018100

PRIDE project URI

• PRIDE
  1. PXD018100
     1. Label: PRIDE project
     2. Name: Toxicity of Ppz1 protein phosphatase involves multiple targets