PXD018046-1

PXD018046 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteome analysis of signaling by ErbB2 in ovarian cancer cell line(1st approach)
Description	The gene for receptor tyrosine kinase ErbB2 is amplified in breast and ovarian tumours. The linear pathway by which signals through ErbB2 are transduced is well known. However, second generation questions that address spatial aspects of signaling remain. To address this, we have undertaken a mass spectrometry approach to identify phosphoproteins specific for ErbB2 using the inhibitors Lapatinib and CP724714 using affinity chromatography and nano-LC ESI MS/MS
HostingRepository	PRIDE
AnnounceDate	2025-12-29
AnnouncementXML	Submission_2025-12-28_16:05:07.028.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD018046
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Sidhanth Jayprakash
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	Phospho; phosphorylated residue; Oxidation; Carbamidomethyl; monohydroxylated residue; iodoacetamide derivatized residue; Gln->pyro-Glu
Instrument	LTQ Orbitrap Discovery

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-13 04:29:56	ID requested
⏵ 1	2025-12-28 16:05:08	announced

Vaparanta K, Song Z, Farahani I, Jokilammi A, Merilahti J, Ö, rling J, Virtanen N, Haapaniemi P, Sahlgren C, Elenius K, Paatero I, Phosphoproteomic analysis reveals the diversity of signaling behind ErbB-inhibitor-induced phenotypes. FEBS J, 292(24):6557-6575(2025) [pubmed]

10.6019/PXD018046;

10.1111/febs.70197;

submitter keyword: Human, SKOV-3, EGF

Dr.T.S. Ganesan
contact affiliation	Departments of Medical Oncology and Clinical Research, Cancer Institute (WIA), 38 Sardar Patel Road, Guindy, Chennai- 600036
contact email	tsganesan@gmail.com
lab head
Sidhanth Jayprakash
contact affiliation	Cancer Institute(WIA)
contact email	sidhanthsuresh@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD018046

PRIDE project URI

• PRIDE
  1. PXD018046
     1. Label: PRIDE project
     2. Name: Phosphoproteome analysis of signaling by ErbB2 in ovarian cancer cell line(1st approach)