PXD017955-2
PXD017955 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic profiling of potential E6AP and HDAC6 targets in liver cancer cells |
Description | E3 ubiquitin ligase E6AP and histone deacetylase HDAC6 play essential roles in the progress and development of various cancers. To explore the mechanism of E6AP and HDAC6 in liver cancer, we performed proteomic analysis with E6AP knockdown, HDAC6 knockdown and negative control HepG2 cells. We identified proteins were significantly regulated upon knockdown of E6AP or HDAC6. Pathway analysis confirmed the known phenotypic effect of E6AP and HDAC6. Overall, results from our investigation provide potential biological pathways and target genes controlled by E6AP and HDAC6 in liver cancer cells. |
HostingRepository | iProX |
AnnounceDate | 2020-03-11 |
AnnouncementXML | Submission_2020-03-10_18:40:16.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Lihua Ding |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-03-09 20:06:00 | ID requested | |
1 | 2020-03-09 20:08:03 | announced | |
⏵ 2 | 2020-03-10 18:40:17 | announced | 2020-03-11: Update datafiles |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: E6AP, HDAC6, liver cancer |
Contact List
Qinong Ye | |
---|---|
contact affiliation | Beijing Institute of Biotechnology |
contact email | yeqn88@163.com |
lab head | |
Lihua Ding | |
contact affiliation | Beijing Institute of Biotechnology |
contact email | dinglh2004@126.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |