PXD017469-1

PXD017469 is an original dataset announced via ProteomeXchange.

Title	Characterization of signaling pathways associated with pancreatic beta-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db miceCharacterization of signaling pathways associated with pancreatic β-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db mice
Description	To characterize the signaling mechanisms underlying beta-cell dysfunction in db/db mice and their return to a more “normal” beta-cell phenotype, we applied a mass spectrometry-based quantitative phosphophoproteomics and sialiomics(sialylated N-linked glycopeptides) approach to normal and db/db beta-cells from hyperglycemic and euglycemic environments.
HostingRepository	PRIDE
AnnounceDate	2020-05-19
AnnouncementXML	Submission_2020-05-18_17:41:33.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD017469
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Taewook Kang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; Phospho; unknown modification; Deamidated; phosphorylated residue; Oxidation; monohydroxylated residue; Carbamidomethyl; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF; Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-02-12 02:54:26	ID requested
⏵ 1	2020-05-18 17:41:34	announced

Kang T, Boland BB, Jensen P, Alarcon C, Nawrocki A, Grimsby JS, Rhodes CJ, Larsen MR, Mice. Mol Cell Proteomics, 19(6):971-993(2020) [pubmed]

submitter keyword: islets, diabetes, beta-cells, obesity

Martin R. Larsen
contact affiliation	Protein research group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark.
contact email	mrl@bmb.sdu.dk
lab head
Taewook Kang
contact affiliation	University of Southern Denmark
contact email	taewookk@bmb.sdu.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD017469

PRIDE project URI

• PRIDE
  1. PXD017469
     1. Label: PRIDE project
     2. Name: Characterization of signaling pathways associated with pancreatic beta-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db miceCharacterization of signaling pathways associated with pancreatic β-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db mice