PXD017381-1

PXD017381 is an original dataset announced via ProteomeXchange.

Title	Cardiopoietic stem cell therapy restores infarction-altered cardiac proteome
Description	Cardiopoietic stem cells are in advanced clinical testing for ischemic heart failure. To profile their uncharted molecular influence on recipient hearts, systems proteomics was applied in a chronic murine model of infarction randomized with and without human cardiopoietic stem cell treatment. Four biological replicates are included from each of three separate groups, Control (Ctrl, n=4), myocardial infarction without treatment (MI, n=4), and MI with cardiopoietic stem cell treatment (CP, n=4). Athymic nude male mice (2-3 months of age) underwent left anterior descending coronary artery ligation (70-min occlusion followed by reperfusion). ST elevation on the electrocardiogram confirmed MI. Four weeks post-MI, animals were randomized into cohorts without (MI, n=4) or with (CP, n=4) cell therapy. Human CP cells were generated from bone marrow derived mesenchymal stem cells using an established cardiopoiesis protocol. Media (15 µL), with or without CP cells (600,000 cells/heart), were epicardially delivered in infarcted left ventricles.
HostingRepository	PRIDE
AnnounceDate	2020-03-23
AnnouncementXML	Submission_2020-03-23_00:12:39.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	D Kent Arrell
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-02-04 08:24:52	ID requested
⏵ 1	2020-03-23 00:12:40	announced
2	2024-10-22 05:01:27	announced	2024-10-22: Updated project metadata.

Arrell DK, Rosenow CS, Yamada S, Behfar A, Terzic A, Cardiopoietic stem cell therapy restores infarction-altered cardiac proteome. NPJ Regen Med, 5():5(2020) [pubmed]

submitter keyword: Cardiopoiesis, heart failure, proteomics, regenerative medicine, systems biology

Andre Terzic, MD, PhD
contact affiliation	Mayo Clinic Center for Regenerative Medicine Department of Cardiovascular Medicine Rochester, MN, USA
contact email	terzic.andre@mayo.edu
lab head
D Kent Arrell
contact affiliation	Mayo Clinic
contact email	arrell.kent@mayo.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/03/PXD017381

PRIDE project URI

• PRIDE
  1. PXD017381
     1. Label: PRIDE project
     2. Name: Cardiopoietic stem cell therapy restores infarction-altered cardiac proteome