PXD017350-2

PXD017350 is an original dataset announced via ProteomeXchange.

Title	Changes in bovine Lymphocyte proteome after stimulation with pokeweed mitogen
Description	A new vaccine against bovine viral diarrhea (BVD) induced unwanted immune reactions with production of alloreactive antibodies in 5–10% of vaccinated cows. Transfer of these antibodies via colostrum caused bovine neonatal pancytopenia (BNP) in calves, with a lethality rate of 90%. The exact immunological mechanisms behind the onset of BNP are not fully understood to date, however, an immune deviant phenotype of immune cells is assumed. To gain deeper insight into disease onset and pathogenesis, we analyzed the lymphocyte (PBL) proteome from alloreactive antibody producers (BNP cows) and non-responders (controls) after stimulation with PWM.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:33:25.581.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roxane Degroote
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	deaminated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap XL

Revision	Datetime	Status	ChangeLog Entry
0	2020-01-31 04:45:55	ID requested
1	2022-02-22 08:46:12	announced
⏵ 2	2024-10-22 05:33:26	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biological

submitter keyword: Pokeweed mitogen

polyclonal cell stimulation

immune reaction, cow

Cornelia Annette Deeg
contact affiliation	Chair of Physiology, Department of Veterinary Sciences, LMU Munich
contact email	Cornelia.Deeg@lmu.de
lab head
Roxane Degroote
contact affiliation	LMU Munich, Veterinary Sciences, Chair of Physiology, Lena-Christ-Straße 48, 82152 Planegg/Martinsried, Germany
contact email	r.degroote@lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD017350

PRIDE project URI

• PRIDE
  1. PXD017350
     1. Label: PRIDE project
     2. Name: Changes in bovine Lymphocyte proteome after stimulation with pokeweed mitogen