PXD017256-1
PXD017256 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling |
| Description | E3-ubiquitin ligase Cullin3 (Cul3) is a high confidence risk gene for neurodevelopmental disorders including autism spectrum disorder (ASD) and developmental delay (DD). We generated Cul3-haploinsufficient mouse model to investigate brain anatomy, behavior, molecular, cellular, and circuit-level mechanisms dysregulated by Cul3 mutations. Spatiotemporal transcriptomic and proteomic profiling of the brain implicated neurogenesis and cytoskeletal defects as key drivers of Cul3 functional impact. Quantitative proteomic profiling was performed by Tandem Mass Tag (TMT) labeling and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis with SPS-MS3 workflow. |
| HostingRepository | MassIVE |
| AnnounceDate | 2021-03-16 |
| AnnouncementXML | Submission_2021-03-16_19:18:36.207.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Nam-Kyung Yu |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | S-carboxamidomethyl-L-cysteine; unknown modification |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-01-22 11:52:34 | ID requested | |
| ⏵ 1 | 2021-03-16 19:18:36 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: TMT, Cullin3, Autism, Mouse brain |
Contact List
| Lilia Iakoucheva | |
|---|---|
| contact affiliation | UCSD |
| contact email | lilyak@health.ucsd.edu |
| lab head | |
| Nam-Kyung Yu | |
| contact affiliation | Scripps Research |
| contact email | namkyung@scripps.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000084830/ |
to receive all new ProteomeXchange dataset release announcements!
