PXD017219-1

PXD017219 is an original dataset announced via ProteomeXchange.

Title	Protein Tyrosine Phosphatase SHP2 Controls Interleukin-8 Expression in Breast Cancer Cells
Description	Our work highlights a new role of SHP2 in regulating breast cancer progression by enhancing the production and secretion of the pro-metastatic cytokine IL-8. We also provide mechanistic insights into the effects of SHP2 inhibition and its downstream repercussions. Overall, this work enforces the rational for targeting SHP2 in breast cancer in order to reduce local invasion and block the metastatic potential of neoplastic cells.
HostingRepository	PRIDE
AnnounceDate	2022-06-23
AnnouncementXML	Submission_2022-06-23_11:15:40.710.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vytautas Iesmantavicius
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-01-21 00:34:50	ID requested
⏵ 1	2022-06-23 11:15:41	announced
2	2024-10-22 05:37:52	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: Breast cancer, Cytokines, ETS1, IL-8, MAPK, Phosphatase, SHP2

Mohamed Bentires-Alj
contact affiliation	Department of Biomedicine (DBM), University Hospital, Basel, Switzerland
contact email	m.bentires-alj@unibas.ch
lab head
Vytautas Iesmantavicius
contact affiliation	Friedrich Miescher Institute for Biomedical Research
contact email	vytautas.iesmantavicius@fmi.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD017219

PRIDE project URI

• PRIDE
  1. PXD017219
     1. Label: PRIDE project
     2. Name: Protein Tyrosine Phosphatase SHP2 Controls Interleukin-8 Expression in Breast Cancer Cells