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PXD017219 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProtein Tyrosine Phosphatase SHP2 Controls Interleukin-8 Expression in Breast Cancer Cells
DescriptionOur work highlights a new role of SHP2 in regulating breast cancer progression by enhancing the production and secretion of the pro-metastatic cytokine IL-8. We also provide mechanistic insights into the effects of SHP2 inhibition and its downstream repercussions. Overall, this work enforces the rational for targeting SHP2 in breast cancer in order to reduce local invasion and block the metastatic potential of neoplastic cells.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterVytautas Iesmantavicius
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-01-21 00:34:50ID requested
12022-06-23 11:15:41announced
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biomedical
submitter keyword: Breast cancer, Cytokines, ETS1, IL-8, MAPK, Phosphatase, SHP2
Contact List
Mohamed Bentires-Alj
contact affiliationDepartment of Biomedicine (DBM), University Hospital, Basel, Switzerland
contact emailm.bentires-alj@unibas.ch
lab head
Vytautas Iesmantavicius
contact affiliationFriedrich Miescher Institute for Biomedical Research
contact emailvytautas.iesmantavicius@fmi.ch
dataset submitter
Full Dataset Link List
Dataset FTP location
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