PXD017201 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | In-depth plasma proteomics in patients with metastatic cutaneous melanoma treated with immune checkpoint inhibitors or MAPK-inhibitors |
Description | Recent development of new therapies with immune checkpoint inhibitors (ICIs) and MAPK-inhibitors (MAPKis) have significantly improved the outcome in metastatic cutaneous melanoma (CM). However, therapy response is limited to subgroups of patients and clinically useful predictive biomarkers for treatment outcome are lacking. To discover treatment-related systemic changes in plasma and potential biomarkers associated with treatment outcomes, we analysed 45 plasma samples with HiRIEF LC-MS/MS, collected before (pre-trm) and during treatment (trm). Of these, 27 samples were taken from 15 metastatic CM patients treated with ICIs (13 pre-trm and 14 trm samples; 12 matched) and 9 patients treated with MAPKis (9 matched). Matched samples were trm and pre-trm samples taken from the same individual before treatment and after the first cycle of treatment (before the second cycle), with a median of 20 days between samples (range: 7-57, SD: 10.26). We have analysed the change in the plasma protein levels during treatment, by comparing the plasma levels in the trm samples to the pre-trm samples, to detect treatment-induced alterations in the plasma proteome. We have analysed the patients treated with ICIs separately from the patients with MAPKis, to detect treatment-specific changes for both. |
HostingRepository | PRIDE |
AnnounceDate | 2020-05-06 |
AnnouncementXML | Submission_2020-05-05_22:42:47.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Haris Babačić |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-01-20 06:03:30 | ID requested | |
⏵ 1 | 2020-05-05 22:42:48 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: metastatic, melanoma, plasma, immune checkpoint inhibitors, MAPK, MAPK-inhibitors, programmed cell death protein 1, nivolumab, ipilimumab, vemurafenib, dabrafenib, trametinib, biomarkers, HiRIEF, LC-MS/MS |
Contact List
Janne Lehtiö |
contact affiliation | Dept. of Oncology-Pathology, Karolinska Institutet, Scilifelab, Stockholm, Sweden |
contact email | janne.lehtio@ki.se |
lab head | |
Haris Babačić |
contact affiliation | 1. Department of Oncology-Pathology, Karolinska Institute, Stockholm; 2. Proteogenomics Facility, Science for Life Laboratory |
contact email | haris.babacic@ki.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD017201
- Label: PRIDE project
- Name: In-depth plasma proteomics in patients with metastatic cutaneous melanoma treated with immune checkpoint inhibitors or MAPK-inhibitors