PXD017026 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mass spectrometry-based characterisation of human megakaryocyte CRLF3 interactome |
Description | Cytokine-receptor like factor 3 (CRLF3) is a protein with an as yet unknown function. CRLF3 has been shown to interact with the members of the Hippo pathway in HEK cells but the function of this interaction was not elucidated. Crlf3 null mice are viable and health but present with an isolated reduced platelet count from birth, confirming CRLF3 has a role in platelet production. We performed affinity purification followed by liquid chromatography coupled to tandem mass spectrometry to identify CRLF3’s binding partners in human megakaryocytes. |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-04 |
AnnouncementXML | Submission_2022-02-04_03:46:31.714.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Cavan Bennett |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-01-09 00:58:22 | ID requested | |
⏵ 1 | 2022-02-04 03:46:32 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological |
submitter keyword: CRLF3, LC-MS/MS, megakaryocyte, human |
Contact List
Cedric Ghevaert |
contact affiliation | Senior Lecturer in Transfusion Medicine / Consultant Haematologist, University of Cambridge / NHS Blood and Transplant, Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, United Kingdom |
contact email | cg348@cam.ac.uk |
lab head | |
Cavan Bennett |
contact affiliation | Department of Haematology, University of Cambridge |
contact email | cavanbennett89@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD017026 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD017026
- Label: PRIDE project
- Name: Mass spectrometry-based characterisation of human megakaryocyte CRLF3 interactome