PXD016995-1

PXD016995 is an original dataset announced via ProteomeXchange.

Title	Proteomic Analysis of Proteins Downstream of Autism-Associated Gene DIXDC1
Description	Dix domain containing 1 (Dixdc1) is an important regulator of neuronal development including cortical neurogenesis, neuronal migration and synaptic connectivity, and sequence variants in the gene have been linked to autism spectrum disorders (ASD). Previous studies indicate that Dixdc1 controls neurogenesis through Wnt signaling, while its regulation of dendrite and synapse development requires Wnt and cytoskeletal signaling. However, the prediction of these signaling pathways is primarily based on the structure of Dixdc1. Given the role of Dixdc1 in neural development and brain disorders, we hypothesized that Dixdc1 may regulate additional signaling pathways in the brain. We performed proteomic analyses of Dixdc1 KO mouse cortices to reveal such alterations.
HostingRepository	PRIDE
AnnounceDate	2020-12-21
AnnouncementXML	Submission_2020-12-21_03:54:59.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yu Lu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-01-07 07:06:28	ID requested
⏵ 1	2020-12-21 03:54:59	announced

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: autism spectrum disorder, DISDC1, mouse, brain

Yu Lu
contact affiliation	Department of Biochemistry and Biomedical Sciences McMaster University
contact email	yu.lu@mcmaster.ca
lab head
Yu Lu
contact affiliation	McMaster University
contact email	yu.lu@mcmaster.ca
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD016995
     1. Label: PRIDE project
     2. Name: Proteomic Analysis of Proteins Downstream of Autism-Associated Gene DIXDC1