PXD016890-1
PXD016890 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Effects of mobile phone electromagnetic radiation on rat hippocampus proteome |
| Description | Worldwide, number of mobile phone users have increased from 5.57 billion in 2011 to 6.8 billion in 2019. However short and long term impacts of the electromagnetic radiations emitting of mobile phone on tissue homeostasis with particular to brain proteome composition needs further investigation. In this study, we attempted a global proteome profiling study of rat hippocampus exposed to mobile phone radiation for 20 weeks (for 3 hrs/day for 5 days/week) to identify deregulated proteins and western blot analysis for validation. As a result, we identified 358 hippocampus proteins, of which 16 showed deregulation (log2 (exposed vs control). Majority of these deregulated proteins grouped to three clusters sharing similar molecular functions/pathways. A set of four proteins (Aldehyde dehydrogenase:Aldh5a1, Na+ K+ transporting ATPase:Atp1b2, plasma membrane calcium transporting ATPase:PMCA and protein S100b) presenting each functional pathways were selected as important molecules. Western blot analysis of this protein set, expect Atp1b2, in independent samples corroborated the mass spectrometry findings. Aldh5a1 involve in cellular energy metabolism, both Atp1b2 and PMCA responsible for membrane transport and protein S100b has neuroprotective role. In conclusion, we present deregulated hippocampus proteome upon mobile phone radiation which might impact healthy functioning of brain. |
| HostingRepository | MassIVE |
| AnnounceDate | 2020-01-02 |
| AnnouncementXML | Submission_2020-01-02_08:26:57.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | vandana singh |
| SpeciesList | scientific name: Rattus norvegicus; common name: Norway rat; NCBI TaxID: 10116; |
| ModificationList | unknown modification |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-12-20 23:41:06 | ID requested | |
| ⏵ 1 | 2020-01-02 08:26:58 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Mobile phone, Electromagnetic Radiation, Hippocampus, Proteome, iTRAQ |
Contact List
| Dr. Ranjan Kumar Nanda | |
|---|---|
| contact affiliation | International Center for Genetic Engineering and Biotechnology, New Delhi, INDIA |
| contact email | ranjan@icgeb.res.in |
| lab head | |
| vandana singh | |
| contact affiliation | Jawaharlal Nehru University |
| contact email | kumari70_sbt@jnu.ac.in |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000084732/ |
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