PXD016810-2

PXD016810 is an original dataset announced via ProteomeXchange.

Title	Toxoplasma gondii eIF-5A knockdown iTraq
Description	Proliferative stage (tachyzoite) is a critical factor in the transmission and pathogenesis of Toxoplasma gondii (T. gondii), which is capable of infecting a large variety of host cells. Proto-oncogene eukaryotic translation initiation factor (eIF-5A) is thought to function in regulation of many cellular processes including cell proliferation. Investigation the specific roles of eIF-5A involved in T. gondii is instrumental for the elucidation of tachyzoite replication. Here, eIF-5A knockdown strain was generated and analyzed by isobaric tags for relative and absolute quantification (iTraq), which suggested that proto-oncogene eIF-5A also acts as an essential gene to ensure proper protein synthesis during T. gondii invasion and replication.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:26:57.592.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	xiangrui Li
SpeciesList	scientific name: Toxoplasma gondii RH; NCBI TaxID: 383379;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-18 01:25:50	ID requested
1	2021-09-08 17:07:53	announced
⏵ 2	2024-10-22 05:27:05	announced	2024-10-22: Updated project metadata.

Liu X, Li C, Li X, Ehsan M, Lu M, Li K, Xu L, Yan R, Song X, Li X, Proteomics analysis reveals that the proto-oncogene eIF-5A indirectly influences the growth, invasion and replication of Toxoplasma gondii tachyzoite. Parasit Vectors, 14(1):283(2021) [pubmed]

10.1186/s13071-021-04791-6;

submitter keyword: Toxoplasma gondii,iTraq

Li xiangrui
contact affiliation	MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, PR China
contact email	lixiangrui@njau.edu.cn
lab head
xiangrui Li
contact affiliation	Nanjing Agricultural University
contact email	lixiangrui@njau.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD016810

PRIDE project URI

• PRIDE
  1. PXD016810
     1. Label: PRIDE project
     2. Name: Toxoplasma gondii eIF-5A knockdown iTraq