PXD016640 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Robust ligand-protein interaction inference reveals off-targets of epigenetic drugs |
Description | Detecting target engagement is a major challenge in drug discovery. To this end, thermal proteome profiling (TPP) offers unbiased assessment of system-wide ligand-protein interactions. However, its most sensitive assay format lacks statistical methods with false discovery rate-control. Here, we present FILIP, a functional data analysis approach and showcase its performance on several TPP-datasets probing epigenetic drugs. This leads us to identify drug off-targets which we validate in vitro. |
HostingRepository | PRIDE |
AnnounceDate | 2020-10-29 |
AnnouncementXML | Submission_2020-10-28_23:41:59.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Nils Kurzawa |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-12-06 06:51:51 | ID requested | |
⏵ 1 | 2020-10-28 23:42:00 | announced | |
2 | 2020-12-04 01:06:58 | announced | 2020-12-04: Updated publication reference for PubMed record(s): 33188197. |
3 | 2024-10-22 05:14:27 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: TPP, epigenetic drugs |
Contact List
Marcus Bantscheff |
contact affiliation | Cellzome, a GSK company, Heidelberg, Germany |
contact email | marcus.x.bantscheff@gsk.com |
lab head | |
Nils Kurzawa |
contact affiliation | EMBL Heidelberg |
contact email | nils.kurzawa@embl.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/10/PXD016640 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016640
- Label: PRIDE project
- Name: Robust ligand-protein interaction inference reveals off-targets of epigenetic drugs