PXD016550-2

PXD016550 is an original dataset announced via ProteomeXchange.

Title	HHIP-AS1 lncRNA promotes tumorigenicity in human SHH-driven brain tumors
Description	Long non-coding RNAs (lncRNAs) comprise a diverse class of gene expression regulators with emerging roles in many biological processes including cancer. Here we show that the expression of the lncRNA Hedgehog Interacting Protein Antisense 1 (HHIP-AS1) is a hallmark feature of human SHH-driven tumors. Importantly, loss of HHIP-AS1 leads to reduced tumor growth in SHH-driven tumors in vitro and in vivo. Our results demonstrate the power of cross-entity transcriptome-wide comparisons to identify novel epigenetic–regulatory lncRNA circuitries underlying human cancers.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:37:26.236.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nina Overbeck
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	methionine oxidation with neutral loss of 80 Da; iodoacetic acid derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-03 04:37:55	ID requested
1	2022-06-01 12:12:47	announced
⏵ 2	2024-10-22 05:37:26	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: pediatric brain tumors,lncRNA, epigenetic regulation, SHH, proteogenomic

Kai Stühler
contact affiliation	Institute for Molecular Medicine I, Medical Faculty, Heinrich-Heine-University Duesseldorf, Universitaetsstrasse 1, 40225 Duesseldorf, Germany
contact email	kai.stuehler@hhu.de
lab head
Nina Overbeck
contact affiliation	BMFZ/MPL
contact email	nina.overbeck@hhu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD016550

PRIDE project URI

• PRIDE
  1. PXD016550
     1. Label: PRIDE project
     2. Name: HHIP-AS1 lncRNA promotes tumorigenicity in human SHH-driven brain tumors