PXD016413 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Degrasyn exhibits antibiotic activity against multi-resistant Staphylococcus aureus by modifying several essential cysteines |
| Description | In this dataset, we investigate the targets of degrasyn in the methicillin-sensitive S. aureus strain NCTC 8325. This includes data on enrichment studies and competition studies with conventional ABPP using a degrasyn-derived probe, competition studies with residue-specific proteomics using the isoDTB-ABPP method and global analysis of protein expression levels in response to degrasyn treatment. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_05:02:06.066.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Stephan M. Hacker |
| SpeciesList | scientific name: Staphylococcus aureus; NCBI TaxID: 1280; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion; Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2019-11-25 00:38:03 | ID requested | |
| 1 | 2020-04-13 22:33:26 | announced | |
| ⏵ 2 | 2024-10-22 05:02:12 | announced | 2024-10-22: Updated project metadata. |
Publication List
| 10.1039/c9cc09204h; |
| Lee KM, Le P, Sieber SA, Hacker SM, Degrasyn exhibits antibiotic activity against multi-resistant Staphylococcus aureus by modifying several essential cysteines. Chem Commun (Camb), 56(19):2929-2932(2020) [pubmed] |
Keyword List
| curator keyword: Biomedical |
| submitter keyword: Chemoproteomics,Antibioitcs, S. aureus, isoDTB-ABPP |
Contact List
| Stephan A. Sieber |
|---|
| contact affiliation | Department of Chemistry, Technische Universität München, Garching bei München, Germany. |
| contact email | stephan.sieber@tum.de |
| lab head | |
| Stephan M. Hacker |
|---|
| contact affiliation | Technical University of Munich |
| contact email | stephan.m.hacker@tum.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/04/PXD016413 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016413
- Label: PRIDE project
- Name: Degrasyn exhibits antibiotic activity against multi-resistant Staphylococcus aureus by modifying several essential cysteines
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