PXD016384-1

PXD016384 is an original dataset announced via ProteomeXchange.

Title	Acetylome analysis of Bordetella pertussis reveals possible targets of novel BP0960 gene-encoded lysine deacetylase
Description	Acetylation on ε-amino groups of lysine residues (N-ε-lysine acetylation) represents an important mechanism of post-translational regulation of protein function. However, its role and extent in the whooping cough agent Bordetella pertussis remain unknown. In this study, we analyzed the acetylomes of two bacterial mutants lacking putative lysine deacetylases encoded by genes BP0960 and BP3063 and compared them with the acetylome of wild-type B. pertussis. The results suggest that acetylation on lysine residues may modulate the activities of proteins involved in bacterial virulence and of multiple histone-like proteins.
HostingRepository	PRIDE
AnnounceDate	2020-07-19
AnnouncementXML	Submission_2020-07-18_18:32:45.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ivo Fabrik
SpeciesList	scientific name: Bordetella pertussis Tohama I; NCBI TaxID: 257313;
ModificationList	acetylated residue; monohydroxylated residue; N6-acetyl-L-lysine; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2019-11-21 06:51:11	ID requested
⏵ 1	2020-07-18 18:32:46	announced
2	2024-10-22 05:09:31	announced	2024-10-22: Updated project metadata.

Novak J, Fabrik I, Jurnecka D, Holubova J, Stanek O, Sebo P, Acetylome is Shaped by Lysine Deacetylase Bkd1. J Proteome Res, 19(9):3680-3696(2020) [pubmed]

submitter keyword: Bordetella pertussis, Acetylome, Deacetylase activity

Prof. Peter Sebo, PhD.
contact affiliation	Laboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic
contact email	sebo@biomed.cas.cz
lab head
Ivo Fabrik
contact affiliation	Biomedical Research Center, University Hospital Hradec Kralove
contact email	ivo.fabrik@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/07/PXD016384

PRIDE project URI

• PRIDE
  1. PXD016384
     1. Label: PRIDE project
     2. Name: Acetylome analysis of Bordetella pertussis reveals possible targets of novel BP0960 gene-encoded lysine deacetylase