PXD016230 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Synaptic transmission induces site specific changes in sialylation on N-linked glycoproteins in nerve terminals |
Description | Synaptic transmission is an ultra-fast process that aims at transducing a signal from one neuron to another neuron or cell by the release of neurotransmitters. This process requires rapid response which can be transmitted through fast molecular switches such as post-translational modifications of proteins. We aimed at investigating the potential importance in dynamic modulation of sialic acids on N-linked glycoproteins that are essential for the synaptic transmission process. For this, we characterize site-specific alteration in sialylated N-linked glycosylation in the active zone of rat nerve terminals (synaptosomes) after depolarization by using quantitative sialiomics. |
HostingRepository | PRIDE |
AnnounceDate | 2020-06-11 |
AnnouncementXML | Submission_2020-06-11_15:18:39.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Inga Boll |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-11-11 08:11:50 | ID requested | |
⏵ 1 | 2020-06-11 15:18:42 | announced | |
Publication List
Boll I, Jensen P, Schw, รค, mmle V, Larsen MR, linked Glycoproteins in Rat Nerve Terminals. Mol Cell Proteomics, 19(9):1418-1435(2020) [pubmed] |
Keyword List
submitter keyword: Synaptosomes, Rat, LC-MS/MS, Sialic acid, N-glycosylation, synaptic transmission |
Contact List
Martin R. Larsen |
contact affiliation | Department of Biochemistry and Molecular Biology, University of Southern Denmark, Denmark |
contact email | mrl@bmb.sdu.dk |
lab head | |
Inga Boll |
contact affiliation | University of Southern Denmark |
contact email | ingaboll@bmb.sdu.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD016230 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016230
- Label: PRIDE project
- Name: Synaptic transmission induces site specific changes in sialylation on N-linked glycoproteins in nerve terminals