PXD016223-2

PXD016223 is an original dataset announced via ProteomeXchange.

Title	Data in support of Omics investigation of the Intestinal inflammation and Gut Microbiota in ABCB1a Gene Knock-Out Mouse model
Description	Colon cancer (CRC) and chronic inflammatory bowel disease (IBD) are two common gastrointestinal diseases that have a high impact on the quality of life of the affected individuals and their families as well as on the society. The aim of the present study was to contribute to the understanding of the underlying biological mechanisms of how abcb1 affects the development of colitis and potential environmental interactions. Additionally, we want to form a basis for future studies using the abcb1/mdr1a knockout model. Therefore, we characterized the model using quantitative mass spectrometry based proteomics of colon, ileum and urine as well and gut microbiota by Next-Genome-Sequencing (16SRNA). Additionally, we evaluated the effect of an environmental factor, intake of red meat, using this model.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:06:48.076.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Allan Stensballe
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-11-11 02:41:52	ID requested
1	2023-10-24 10:50:28	announced
⏵ 2	2023-11-14 09:06:53	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:08:15	announced	2024-10-22: Updated project metadata.

Stensballe A, Bennike TB, Ravn-Haren G, Mortensen A, Aboo C, Knudsen LA, R, ü, hlemann MC, Birkelund S, Bang C, Franke A, Vogel U, Hansen AK, Andersen V, Impaired Abcb1a function and red meat in a translational colitis mouse model induces inflammation and alters microbiota composition. Front Med (Lausanne), 10():1200317(2023) [pubmed]

submitter keyword: proteomics,abcb1, ibd, CRC

Allan Stensballe
contact affiliation	Aalborg University
contact email	as@hst.aau.dk
lab head
Allan Stensballe
contact affiliation	Aalborg University
contact email	as@hst.aau.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD016223

PRIDE project URI

• PRIDE
  1. PXD016223
     1. Label: PRIDE project
     2. Name: Data in support of Omics investigation of the Intestinal inflammation and Gut Microbiota in ABCB1a Gene Knock-Out Mouse model