PXD016202-1

PXD016202 is an original dataset announced via ProteomeXchange.

Title	The regulator PltZ senses exogenous2,4-DAPG and regulate a novel multidrug resistant pump in involved in Pseudomonas aeruginosaATCC27853
Description	2, 4-diacetylphloroglucinol (2,4-DAPG) is secondary metabolites produced by soil rhizophsere bacterium Pseudomonas fluorescens with ability to against bacteria,fungi, oomycetes and nematodes. Pseudomonas aeruginos is considered to be one cause of nosocomial infection due to its multi-drug resistance. We found aromatic polyketide antibiotic2,4-DAPG promotes the expression ofmultidrug efflux pumpsgenes pltIJK by blocking the interaction between pltI promoter andTetR family transcription factor PltZin P. aeruginosa; and our proteomics data estsblished thatPltZ is involved in diverse physiological process including metabolism of amino acids, biosynthesis of virulence factors, motility, ion transporting, carbohydrate and lipid transporting.We described asophisticated ATP-binding cassette(ABC)transportsystems regulation mechanismwhich affords insights into the role ofaromatic polyketide antibiotics.
HostingRepository	PRIDE
AnnounceDate	2020-01-17
AnnouncementXML	Submission_2020-01-17_00:26:12.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	yu xiaoquan
SpeciesList	scientific name: Pseudomonas aeruginosa LESB58; NCBI TaxID: 557722;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2019-11-08 01:33:05	ID requested
⏵ 1	2020-01-17 00:26:13	announced
2	2020-08-04 23:14:45	announced	2020-08-05: Updated publication reference for PubMed record(s): 32733400.

Dataset with its publication pending

submitter keyword: 2,4-DAPG, Pseudomonas aeruginosa, PltZ

Yong-Xing He
contact affiliation	Lanzhou University
contact email	heyx@lzu.edu.cn
lab head
yu xiaoquan
contact affiliation	Lanzhou University
contact email	csu_yxq@163.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD016202
     1. Label: PRIDE project
     2. Name: The regulator PltZ senses exogenous2,4-DAPG and regulate a novel multidrug resistant pump in involved in Pseudomonas aeruginosaATCC27853