PXD016137 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Streptococcus pneumoniae infection and murine hearat proteome |
Description | For the last two decades, the three most common causes of death world-wide have been ischemic heart disease, cerebrovascular disease and respiratory tract infections; the latter being caused mainly by the influenza virus and the bacterial pathogen Streptococcus pneumoniae (Spn). Reports through this period of time have shown that elderly patients admitted to the hospital for severe community-acquired pneumonia (CAP), experience ~10-25% mortality rates and up to 40% of them expired within one year. A key contributing factor for the observed high mortality rate are the major adverse cardiac events (MACE) that occur during hospitalization and convalescence9. Notably, during severe pneumococcal infections, Spn, the most common cause of CAP, has been shown to be capable of myocardial invasion, induction of cardiomyocyte death, and disruption of cardiac contractility. In addition, changes to heart functionality have also been reported after influenza infection in humans, however the mechanisms for this remain unclear. |
HostingRepository | PRIDE |
AnnounceDate | 2021-12-23 |
AnnouncementXML | Submission_2021-12-23_11:06:31.135.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yanbao Yu |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Streptococcus pneumoniae TIGR4; NCBI TaxID: 170187; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-11-04 08:36:39 | ID requested | |
⏵ 1 | 2021-12-23 11:06:31 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Heart |
proteome |
remodeling |
Streptococcus pneumoniae |
Contact List
Yanbao Yu |
contact affiliation | J. Craig Venter Institute, Rockville, MD 20850 |
contact email | yayu@jcvi.org |
lab head | |
Yanbao Yu |
contact affiliation | J. Craig Venter Institute |
contact email | yayu@jcvi.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016137
- Label: PRIDE project
- Name: Streptococcus pneumoniae infection and murine hearat proteome