PXD016096 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A pilot proteomic study reveals different protein profiles related to testosterone and gonadotropin changes in a short-term controlled healthy human cohort |
Description | Testosterone deficiency afflicts approximately 30% of men aged from 40-89 years. It is associated with type 2 diabetes, metabolic syndrome and cardiovascular disease. However, the causality of the relationship between low testosterone and metabolic diseases is unclear. We have analysed plasma samples from thirty healthy male volunteers (19-32 years of age) with pharmacologically-induced testosterone deficiency. Blood samples were collected under three conditions: normal testosterone (baseline), ‘zero’ testosterone and ‘restored’ testosterone. As a proof-of-concept, a sample pooling approach was used to obtain one pool per condition, with each pool consisting of 30 individual samples. The proteomic profiles identified significant functional differences, related to the innate immune system, the regulation of insuline-like growth factors, collagen degradation, glycolysis/gluconeogenesis process, among others. |
HostingRepository | PRIDE |
AnnounceDate | 2020-08-03 |
AnnouncementXML | Submission_2020-08-02_22:30:13.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Aniel Sanchez |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-10-31 04:37:38 | ID requested | |
⏵ 1 | 2020-08-02 22:30:14 | announced | |
Publication List
Pla I, Sahlin KB, Paw, ł, owski K, Appelqvist R, Marko-Varga G, Sanchez A, Malm J, A pilot proteomic study reveals different protein profiles related to testosterone and gonadotropin changes in a short-term controlled healthy human cohort. J Proteomics, 220():103768(2020) [pubmed] |
Keyword List
submitter keyword: Testosterone, proteomcis, mass spectrometry |
Contact List
Johan Malm |
contact affiliation | Department of translation medicine. |
contact email | johan.malm@med.lu.se |
lab head | |
Aniel Sanchez |
contact affiliation | Lund University |
contact email | aniel.sanchez@med.lu.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016096
- Label: PRIDE project
- Name: A pilot proteomic study reveals different protein profiles related to testosterone and gonadotropin changes in a short-term controlled healthy human cohort