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PXD016071-1

PXD016071 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAnalysis of the serum peptidome associated with Toxoplasma gondii infection
DescriptionToxoplasma gondii is an obligate intracellular parasite that can cause severe disease in immunocompromised individuals and congenitally infected neonates. In order to determine whether serum peptide profile would reveal disease markers or allow determination of toxoplasmosis aggressiveness, mouse sera were collected from acutely infected, chronically infected and control subjects, and analyzed by using a quantitative label-free pepdomics approach (LC-MS/MS). Six hundred and seven endogenous peptides were identified among all the samples, with peptide profiling of difference that readily distinguished between acutely infected samples and other samples. Among these peptides detected in this study, 81 and 68 differentially expressed peptides (DEPs) were found in the acute and chronic infection stages, respectively. Through Gene Ontology analysis, most of the precursor proteins of these DEPs were associated with biological regulation and binding activity. The findings in this study will help in the search of peptide targets with a key role in disease diagnosis and create new opportunities for the development of better means for toxoplasmosis prevention.
HostingRepositoryiProX
AnnounceDate2019-10-30
AnnouncementXMLSubmission_2020-01-01_19:56:03.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChunxue Zhou
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-10-29 20:13:10ID requested
12020-01-01 19:56:03announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Toxoplasma gondii, serum, peptedome, mouse
Contact List
Shenyi He
contact affiliationShandong university
contact emailshenyihe@sdu.edu.cn
lab head
Chunxue Zhou
contact affiliationShandong university
contact emailzhouchunxue23@163.com
dataset submitter
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