PXD015951 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Canine pyometra - plasma proteomics |
Description | Canine pyometra is a common inflammatory disease of the uterus in sexually mature bitches, caused by a secondary bacterial infection which leads to change in the plasma protein associated with the innate immune system. Proteomic offers a means to determine the profile of plasma in dogs with pyometra to provide important findings into general mechanisms operating during diverse inflammatory reactions. The plasma protein profile of healthy and pyometra affected bitches was determined by means of an isobaric tandem mass tag (TMT) label-based high-resolution quantitative proteomic approach. Six clinically healthy dogs (used as control group) and 6 dogs with pyometra were enrolled in the study. All dogs were admitted to the Small Animal Clinic, University of Veterinary Medicine Hannover and treated in accordance with the German Animal Welfare Law. The experimental design was approved by the Animal Welfare officer of the University of Veterinary Medicine and by the Ethic Committee of the responsible authority (Lower Saxony State Office for Consumer Protection and Food Safety, reference number 17A 101). Healthy dogs for blood collection were recruited by launching a call in the University of Veterinary Medicine Hannover network for students and staff members for haemostasis study, providing a free clinical and laboratory health check of their animal in combination with the blood collection. Residual sample material was used in the present study. |
HostingRepository | PRIDE |
AnnounceDate | 2020-05-18 |
AnnouncementXML | Submission_2020-05-18_00:54:40.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Anita Horvatic |
SpeciesList | scientific name: Canis lupus familiaris; NCBI TaxID: 9615; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-10-22 01:25:37 | ID requested | |
⏵ 1 | 2020-05-18 00:54:41 | announced | |
Publication List
Kule, š J, Horvati, ć A, Guillemin N, Ferreira RF, Mischke R, Mrljak V, Chadwick CC, Eckersall PD, The plasma proteome and the acute phase protein response in canine pyometra. J Proteomics, 223():103817(2020) [pubmed] |
Keyword List
submitter keyword: Dog, pyometra, proteomics, serum, TMT |
Contact List
Peter David Eckersall |
contact affiliation | VetMedZg Laboratory,Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia Institute of Biodiversity, Animal Health & Comparative Medicine, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, UK |
contact email | David.Eckersall@glasgow.ac.uk |
lab head | |
Anita Horvatic |
contact affiliation | University of Zagreb, Faculty of Veterinary Medicine |
contact email | horvatic.ani@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD015951
- Label: PRIDE project
- Name: Canine pyometra - plasma proteomics