PXD015943-2

PXD015943 is an original dataset announced via ProteomeXchange.

Title	Chemical phosphoproteomics reveals kinase network topologies associated to genotypes and phenotypes of cancer cells.
Description	We compare the in vitro specificity profiles of several kinase inhibitors with their effects on cellular phosphoproteomes. For this aim, we developed an algorithm which utilizes information on kinase inhibitor selectivity to determine the most probable kinase(s) acting upstream of phosphorylation sites present in phosphoproteomics data obtained from cancer cells treated with kinase inhibitors.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:05:02.127.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maruan Hijazi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; deaminated residue; monohydroxylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-21 08:31:27	ID requested
1	2020-01-29 12:55:38	announced
⏵ 2	2024-10-22 04:05:10	announced	2024-10-22: Updated project metadata.

Hijazi M, Smith R, Rajeeve V, Bessant C, Cutillas PR, Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring. Nat Biotechnol, 38(4):493-502(2020) [pubmed]

10.1038/s41587-019-0391-9;

curator keyword: Biomedical

submitter keyword: phosphoproteomics, kinase signaling networks, cancer, kinase inhibitors, bioinformatics

Pedro Cutillas
contact affiliation	Barts Cancer Institute. Queen Mary University of London
contact email	p.cutillas@qmul.ac.uk
lab head
Maruan Hijazi
contact affiliation	University of Salamanca
contact email	m.hijazivega@qmul.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD015943

PRIDE project URI

• PRIDE
  1. PXD015943
     1. Label: PRIDE project
     2. Name: Chemical phosphoproteomics reveals kinase network topologies associated to genotypes and phenotypes of cancer cells.