PXD015789 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis |
Description | The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. Most studies have found it to be an inhibitor of mitochondrial oxidative phosphorylation (OXPHOS) and an inducer of the Warburg phenotype of cancer cells. However, others have reported the opposite and there is no consensus on the relevant TRAP1 interactors. This calls for a more comprehensive analysis of the TRAP1 interactome and of how TRAP1 and mitochondrial metabolism mutually affect each other. |
HostingRepository | PRIDE |
AnnounceDate | 2020-01-16 |
AnnouncementXML | Submission_2020-01-16_00:43:33.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jon (Jian-Jiang) Hao |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-10-11 01:17:49 | ID requested | |
⏵ 1 | 2020-01-16 00:59:03 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: HSP90, TRAP1, oxidative phosphorylation, glutamine, mitochondria, molecular chaperone, ATP synthase, Proteomics |
Contact List
Didier Picard |
contact affiliation | Département de Biologie Cellulaire Université de Genève Sciences III 30, quai Ernest-Ansermet CH - 1211 Genève 4, Switzerland |
contact email | didier.picard@unige.ch |
lab head | |
Jon (Jian-Jiang) Hao |
contact affiliation | Poochon Scientific |
contact email | jon.hao@poochonscientific.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD015789 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD015789
- Label: PRIDE project
- Name: The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis