PXD015767-2

PXD015767 is an original dataset announced via ProteomeXchange.

Title	SMOC1 as a therapeutic target for type 2 diabetes
Description	Inter-tissue communication is a fundamental feature of systemic metabolic regulation and the liver is central to this process. We have identified sparc-related modular calcium-binding protein 1 (SMOC1) as a glucose-responsive hepatokine and potent regulator of glucose homeostasis. Acute administration of recombinant SMOC1 improves glycemic control and insulin sensitivity, independent of changes in insulin secretion. SMOC1 exerts its favourable glycemic effects by inhibiting cAMP-PKA-CREB signaling in the liver, leading to decreased gluconeogenic gene expression and suppression of hepatic glucose output. Over expression of SMOC1 in the liver or once-weekly injections of a stabilized SMOC1-FC fusion protein induces durable improvements in glucose tolerance and insulin sensitivity in db/db mice, without significant adverse effects on adiposity, liver histopathology or inflammation. Furthermore, SMOC1 correlates with systemic insulin sensitivity and is decreased in obese, insulin resistant humans. Together, these findings identify SMOC1 as a potential pharmacological target for the management of glycemic control in type 2 diabetes.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:11:11.386.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Cheng Huang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-10 01:34:17	ID requested
1	2020-08-20 22:48:40	announced
⏵ 2	2024-10-22 05:11:11	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: SMOC1, type 2 dibetes

Matthew J Watt
contact affiliation	Department of Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, The University of Melbourne, Victoria 3010 Australia
contact email	matt.watt@unimelb.edu.au
lab head
Cheng Huang
contact affiliation	Monash University
contact email	cheng.huang@monash.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD015767
     1. Label: PRIDE project
     2. Name: SMOC1 as a therapeutic target for type 2 diabetes