PXD015766-2

PXD015766 is an original dataset announced via ProteomeXchange.

Title	SEC23B-dependent COPII Vesicles Regulate T Cell Immunity
Description	The coordinated release of proteins by T cells enables controlled biological responses. While the molecular mechanisms underlying T cell secretion are being increasingly understood, whether the critical ER-to-Golgi trafficking pathway regulates T cell immunity is not known. We utilized mice with a T cell-specific deletion of SEC23B, a core subunit of Coat Protein Complex II (COPII) which drives ER-to-Golgi cargo transport. We found that following activation, SEC23B-deficient T cells display an altered secretome compared to wild-type, which includes reduced secretion of T cell-derived inflammatory mediators, and which is associated with functional ramifications in vitro and in vivo. Together, these data reveal a critical role for the SEC23B-dependent COPII pathway in T cell immunity.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:26:32.369.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pavan Reddy
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-10 01:34:17	ID requested
1	2021-09-08 13:42:06	announced
⏵ 2	2024-10-22 05:26:38	announced	2024-10-22: Updated project metadata.

Kim S, Khoriaty R, Li L, McClune M, Kalfa TA, Wu J, Peltier D, Fujiwara H, Sun Y, Oravecz-Wilson K, King RA, Ginsburg D, Reddy P, ER-to-Golgi transport and SEC23-dependent COPII vesicles regulate T cell alloimmunity. J Clin Invest, 131(2):(2021) [pubmed]

10.1172/jci136574;

submitter keyword: LC-MSMS, Lymphocytes,Mouse

Pavan Reddy
contact affiliation	University of Michigan
contact email	reddypr@umich.edu
lab head
Pavan Reddy
contact affiliation	University of Michigan
contact email	reddypr@umich.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD015766
     1. Label: PRIDE project
     2. Name: SEC23B-dependent COPII Vesicles Regulate T Cell Immunity