⮝ Full datasets listing
PXD015507-1
PXD015507 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of CTPS1 Filament Interacting Proteins_2019 dataset |
| Description | CTP synthase (CTPS) catalyzes the formation of CTP in de novo pyrimidine biosynthesis pathway. Compartmentalization of CTPS into filamentous structure is evolutionarily conserved from E.coli, yeast, Drosophila, mice to humans. Previously, we demonstrated that histidine (His) mediated methylation promotes the formation of CTPS filament to suppress the enzymatic activity and preserve CTPS protein under Gln deprivation, which promotes cancer cell growth after stress alleviation. However, it remains unclear where and how these enigmatic structures are assembled. Here we used APEX2-mediated in vivo proximity labeling to identify proteins involve in the formation of human CTPS filaments. |
| HostingRepository | PRIDE |
| AnnounceDate | 2020-03-24 |
| AnnouncementXML | Submission_2020-03-24_03:41:44.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yu-Tsun Lin |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-09-19 02:56:25 | ID requested | |
| ⏵ 1 | 2020-03-24 03:41:45 | announced | |
| 2 | 2024-10-22 05:01:19 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
| submitter keyword: CTPS1, APEX2, TMT6 labeling, LC-MS/MS |
Contact List
| Jau-Song Yu | |
|---|---|
| contact affiliation | Molecular Medicine Research Center, Chang Gung University |
| contact email | yusong@mail.cgu.edu.tw |
| lab head | |
| Yu-Tsun Lin | |
| contact affiliation | Chang Gung University |
| contact email | doreenlin1230@gmail.com |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/03/PXD015507 |
| PRIDE project URI |
Repository Record List
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