PXD015373 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Tissue Thermal Proteome Profiling |
Description | We introduce tissue Thermal Proteome Profiling (tissue-TPP) which enables the discovery of drug targets and off-targets as well as measurements of target occupancy in tissue samples derived from dosed animals. Here we report the first proteome-wide thermal stability map of tissues and organ-specific target profiles of the non-covalent histone deacetylase inhibitor, panobinostat. In addition, we devised blood-CETSA/TPP to monitor target and off-target engagement directly in whole blood. |
HostingRepository | PRIDE |
AnnounceDate | 2020-01-07 |
AnnouncementXML | Submission_2020-02-17_02:23:09.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Nils Kurzawa |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-09-09 04:52:23 | ID requested | |
1 | 2020-01-07 13:46:44 | announced | |
⏵ 2 | 2020-02-17 02:23:10 | announced | 2020-02-17: Updated publication reference for PubMed record(s): 31959954. |
Publication List
Perrin J, Werner T, Kurzawa N, Rutkowska A, Childs DD, Kalxdorf M, Poeckel D, Stonehouse E, Strohmer K, Heller B, Thomson DW, Krause J, Becher I, Eberl HC, Vappiani J, Sevin DC, Rau CE, Franken H, Huber W, Faelth-Savitski M, Savitski MM, Bantscheff M, Bergamini G, Identifying drug targets in tissues and whole blood with thermal-shift profiling. Nat Biotechnol, 38(3):303-308(2020) [pubmed] |
Keyword List
curator keyword: Technical |
submitter keyword: TPP, Human, Blood |
Contact List
Marcus Bantscheff |
contact affiliation | Cellzome, a GSK company |
contact email | marcus.x.bantscheff@gsk.com |
lab head | |
Nils Kurzawa |
contact affiliation | EMBL Heidelberg |
contact email | nils.kurzawa@embl.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD015373 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD015373
- Label: PRIDE project
- Name: Tissue Thermal Proteome Profiling