PXD015317-1
PXD015317 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression |
| Description | Cholangiocarcinoma is a cancer of the hepatic bile ducts that is typically detected at a stage too advanced for resection. Additionally, chemotherapy is of limited efficacy, hence, novel therapeutic approaches are urgently required, including targeting of the cancer stroma. A macrophage-derived signal, tumour necrosis factor-like weak inducer of apoptosis (TWEAK), binds to cell-surface fibroblast growth factor-inducible 14 (Fn14), on cholangiocarcinoma cells to induce cytokine and chemokine expression and secretion. These TWEAK-inducible factors from cholangiocarcinoma cells can also affect macrophage polarisation. We characterised proteins secreted by four well-characterised human cholangiocarcinoma cell lines in the presence or absence of recombinant human TWEAK (100 ng/ml), to discover novel TWEAK-inducible factors that could drive pro-tumour niche formation. |
| HostingRepository | MassIVE |
| AnnounceDate | 2020-11-24 |
| AnnouncementXML | Submission_2020-11-24_09:37:43.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Dominic Kurian |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Carbamidomethyl; oxidation; Deamidated |
| Instrument | micrOTOF-Q II |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-09-04 06:22:33 | ID requested | |
| ⏵ 1 | 2020-11-24 09:37:44 | announced |
Publication List
| Dwyer BJ, Jarman EJ, Gogoi-Tiwari J, Ferreira-Gonzalez S, Boulter L, Guest RV, Kendall TJ, Kurian D, Kilpatrick AM, Robson AJ, O'Duibhir E, Man TY, Campana L, Starkey Lewis PJ, Wigmore SJ, Olynyk JK, Ramm GA, Tirnitz-Parker JEE, Forbes SJ, TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression. J Hepatol, 74(4):860-872(2021) [pubmed] |
Keyword List
| submitter keyword: Cholangiocarcinoma, niche, stroma, TWEAK, Fn14, inflammation |
Contact List
| Prof.Stuart Forbes | |
|---|---|
| contact affiliation | MRC Centre for Regenerative Medicine, Little France Drive, University of Edinburgh, EH16 4UU |
| contact email | stuart.forbes@ed.ac.uk |
| lab head | |
| Dominic Kurian | |
| contact affiliation | University of Edinburgh |
| contact email | dominic.kurian@roslin.ed.ac.uk |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000084273/ |
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