PXD015213-2

PXD015213 is an original dataset announced via ProteomeXchange.

Title	A snapshot of blood plasma proteomics in clinical response to atypical antipsychotics in schizophrenia – An exploratory study
Description	Antipsychotics are usually the first option to treat schizophrenia; however, for a considerable fraction of patients, it lacks efficacy. Furthermore, there are no known biomarkers to indicate a treatment’s efficacy in a patient. Schizophrenia causes a large socioeconomic burden on countries along with an unquestionable impairment of the quality of life of patients and their relatives. As proteomics can identify, quantify, and characterize proteins in different conditions, it is a powerful tool to study complex diseases such as schizophrenia, also capable of revealing potential biomarkers. To improve treatment efficacy during the early stages of schizophrenia, a critical time period, molecular markers for a positive treatment response were sought. Blood plasma samples were collected in vivo from 26 patients before treatment with the atypical antipsychotics olanzapine and risperidone; they were then classified as good (GR) and poor (PR) responders. We were able to identify a potential panel of proteins that may predict a positive outcome to olanzapine and risperidone treatment. Although still exploratory, this data will assist in the development of personalized medicine strategies with potential clinical implementation
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:06:43.502.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sheila Garcia-Rosa
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-29 04:23:07	ID requested
1	2020-06-01 07:13:36	announced
⏵ 2	2024-10-22 05:06:48	announced	2024-10-22: Updated project metadata.

Garcia-Rosa S, Carvalho BS, Guest PC, Steiner J, Martins-de-Souza D, Blood plasma proteomic modulation induced by olanzapine and risperidone in schizophrenia patients. J Proteomics, 224():103813(2020) [pubmed]

10.1016/j.jprot.2020.103813;

submitter keyword: proteomics, blood plasma, mass spectrometry,schizophrenia, antipsychotics, risperidone, olanzapine.

Daniel Martins-de-Souza
contact affiliation	Dept. of Biochemistry, Laboratory of Neuroproteomic, Biology Institute, Brazil
contact email	dmsouza@unicamp.br
lab head
Sheila Garcia-Rosa
contact affiliation	Universidade Estadual de Campinas (UNICAMP)
contact email	garcia.sheilla@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD015213

PRIDE project URI

• PRIDE
  1. PXD015213
     1. Label: PRIDE project
     2. Name: A snapshot of blood plasma proteomics in clinical response to atypical antipsychotics in schizophrenia – An exploratory study