PXD015125 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Phosphoproteomics analysis of CHK1 inhibitor treatment |
Description | Inhibitors of checkpoint kinase 1 (CHK1),a central component of DNA damage and cell cycle checkpoint response, represent a promising new cancer therapy, but the global cellular functionsthey regulate through phosphorylationare poorly understood. To elucidate the CHK1-regulated phosphorylation network, we performed a global quantitative phosphoproteomics analysis, which revealed 142 phosphositeswhose phosphorylation levels were significantly different following treatment with the CHK1 inhibitor SCH 900776. |
HostingRepository | PRIDE |
AnnounceDate | 2020-04-27 |
AnnouncementXML | Submission_2020-04-26_22:55:16.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Zhen Chen |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-08-22 03:01:45 | ID requested | |
⏵ 1 | 2020-04-26 22:55:18 | announced | |
Publication List
Chen Z, Wang C, Lei C, Feng X, Li C, Jung SY, Qin J, Chen J, Phosphoproteomics Analysis Reveals a Potential Role of CHK1 in Regulation of Innate Immunity through IRF3. J Proteome Res, 19(6):2264-2277(2020) [pubmed] |
Keyword List
submitter keyword: Phosphoprotomics, SILAC, CHK1 inhibitor |
Contact List
Junjie Chen |
contact affiliation | Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center |
contact email | jchen8@mdanderson.org |
lab head | |
Zhen Chen |
contact affiliation | The University of Texas MD Anderson Cancer Center |
contact email | zchen6@mdanderson.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD015125
- Label: PRIDE project
- Name: Phosphoproteomics analysis of CHK1 inhibitor treatment