PXD015074-1

PXD015074 is an original dataset announced via ProteomeXchange.

Title	human glioma cell-line proteomics upon treatment with different drugs
Description	Increasing evidence suggests that induction of lethal autophagy carries potential significance for the treatment of glioblastoma (GBM). In continuation of our previous work, we investigated if autophagy-inducing compunds can trigger ATG-dependent cell death in human MZ-54 GBM cells and which pathways may be affected using TMT10-based quantitative proteomics as one of the tools.
HostingRepository	PRIDE
AnnounceDate	2021-02-26
AnnouncementXML	Submission_2021-02-25_22:29:11.514.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Georg Tascher
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-19 04:46:35	ID requested
⏵ 1	2021-02-25 22:29:12	announced
2	2024-10-22 05:19:36	announced	2024-10-22: Updated project metadata.

Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, M, ü, nch C, Fulda S, Tegeder I, K, ö, gel D, Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy, 17(11):3424-3443(2021) [pubmed]

curator keyword: Biological

submitter keyword: human, glioma, Qexactive HF, TMT10

Christian Münch
contact affiliation	Institute of Biochemistry II, Goethe University Hospital Frankfurt/Main, Germany
contact email	ch.muench@em.uni-frankfurt.de
lab head
Georg Tascher
contact affiliation	Institute of Biochemistry II, Goethe University Hospital Frankfurt/Main, Germany
contact email	tascher@med.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD015074

PRIDE project URI

• PRIDE
  1. PXD015074
     1. Label: PRIDE project
     2. Name: human glioma cell-line proteomics upon treatment with different drugs