PXD015057-1

PXD015057 is an original dataset announced via ProteomeXchange.

Title	Extracellular matrix analysis of human keloid scars
Description	Fibrosis is vaguely described as connective tissue deposition that can be excessive in pathological conditions. This suggests a quantitative spectrum of fibrosis wherein there can be more or less extracellular matrix (ECM), which in the context of a repairing skin wound could reflect the range from normal scar to keloid. This depiction, however, does not encompass the potential qualitative differences between normal and pathological scars. In keloids, the markedly different physical (hard and dense) and histological (hyalinization) characteristics compared to normal scars indicate an altered and inappropriate matrix, rather than simply too much. With this quantitative discovery-based proteomics we provide a thorough molecular description of keloid lesions relative to normal scars, which is an essential step towards our understanding of this problem.
HostingRepository	PRIDE
AnnounceDate	2019-12-03
AnnouncementXML	Submission_2019-12-03_13:23:11.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD015057
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Tanya Shaw
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamidomethyl; Deamidated:18O(1)
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-16 04:53:17	ID requested
⏵ 1	2019-12-03 13:23:11	announced

Dataset with its publication pending

submitter keyword: Human skin scar dermis LC-MS/MS

Tanya Shaw
contact affiliation	King's College London Centre for Inflammation Biology & Cancer Immunology School of Immunology & Microbial Sciences 1st Floor New Hunt's House, Guy's Campus London, UK SE1 1UL
contact email	tanya.shaw@kcl.ac.uk
lab head
Tanya Shaw
contact affiliation	King's College London
contact email	tanya.shaw@kcl.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD015057
     1. Label: PRIDE project
     2. Name: Extracellular matrix analysis of human keloid scars