PXD015000-1

PXD015000 is an original dataset announced via ProteomeXchange.

Title	Differential Proteomic Analysis of Fetal and Geriatric Lumbar Nucleus Pulposus
Description	Intervertebral disc degeneration (IVDD) is a main cause of degenerative disc disease, which results in substantial pain among patients. However, the mechanism of degeneration remains unclear. Thus far, basic research on human IVDD has focused on only a limited number of proteins and has not been conducted from a holistic perspective. In this study, we used tandem mass tag (TMT) labeling combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to perform differential proteomic analysis on fetal and geriatric lumbar disc nucleus pulposus tissue. These data indicate that differential proteomics analysis may be an important method for elucidation of the pathophysiological process and molecular biological mechanism of human IVDD from a holistic perspective. The findings in this study will aid in screening of new biomarkers for early diagnosis and targeted treatment of IVDD.
HostingRepository	iProX
AnnounceDate	2019-12-11
AnnouncementXML	Submission_2020-05-01_20:21:48.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chensheng Qiu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive; Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-12 21:13:02	ID requested
⏵ 1	2020-05-01 20:21:49	announced
2	2020-11-30 00:19:41	announced	2020-11-30: Update publication information

Dataset with its publication pending

submitter keyword: Intervertebral disc degeneration, proteomic analysis

Bohua Chen
contact affiliation	Affiliated Hospital of Qingdao University
contact email	bhchen@hotmail.com
lab head
Chensheng Qiu
contact affiliation	Qingdao University
contact email	qiuchensheng0510@126.com
dataset submitter

iProX dataset URI